Description
GADD45G is a member of GADD45 family (GADD45alpha, beta, and gamma) that are nuclear proteins to interact with various proteins implicated in stress responses and cell-cycle-related proteins. The function of GADD45 proteins is involved in growth-regulatory mechanisms and apoptosis. GADD45G protein responds to environmental stresses by mediating activation of p38/JNK pathway via MTK1/MEKK4 kinase and its transcript levels are increased following stressful growth arrest conditions and treatment with DNA-damaging agents. Recombinant GADD45G protein was expressed in E.coli and purified by using conventional chromatography techniques